Serena's storylines included kissing her cousin's boyfriend, being taken advantage of by a photographer and starting an incestuous relationship with her half-brother.

She is further displeased when she learns she will have to leave Eden Hills Grammar and attend Erinsborough High along with Sky, but this subsides when Serena becomes popular and tries to distance herself from her cousin.

After sneaking into a nightclub and lying about her age, Serena meets barman Chris Cousens (Simon Mallory) who offers her his card and tells her he is a photographer.

At the school formal, Serena flirts with Taj Coppin (Jaime Robbie Reyne) but he tries to put her off by pretending to come on heavy with her.

Later in the evening when Sky is attacked by Erin Perry (Talia Zucker) and her friends, which results in a portable toilet being tipped over, Serena stands by and does nothing to help.

David and Liljana disapprove and Stingray turns to Gino Esposito (Shane McNamara) for help in style and etiquette to impress Serena, which backfires when he eats too much during a date and is sick all over her.

After planning the school formal with Boyd Hoyland (Kyal Marsh), Sky's boyfriend, who has separated from her, Serena shares a kiss with him and they begin a brief relationship.

As 2005 begins, Serena finds her parents at odds after Liljana has an affair with Paul Robinson (Stefan Dennis) and briefly leaves the family.

After this Serena takes a job working for Toadfish Rebecchi (Ryan Moloney) in his bikini shop Bounce, which she later buys into and becomes attracted to Connor (Patrick Harvey).

The Bishop family, along with several of their neighbours board a joy flight to Tasmania arranged by Paul for the 20th anniversary of Lassiter's.

A writer for the BBC's Neighbours website said one of Serena's most notable moments was "Persuading Sky to sneak to a nightclub and then letting her take the blame".