Serena M. Dudek (born 1964; Anaheim, California), is an American neuroscientist known for her work on long-term depression[2][3] and synaptic plasticity in the CA2 region of the hippocampus.

[5][6] Serena Dudek enrolled a Ph.D. program at Brown University where she joined Mark Bear's lab to study long-term depression in a collaboration with Leon Cooper.

[1] On August 26, 2007 with the Duke University Medical Center, Dudek et al published a paper on their research on brain proteins in mice related to Obsessive-compulsive disorder (OCD).

[9] In a Newsweek article called "Buff Your Brain" Serena Dudek and her colleagues' 2011 research on the effects of caffeine in lab rodents was highlighted.

[10] Serena Dudek's research found that rats that were given an equivalent shot of two cups of coffee had stronger electrical activity between neurons in their hippocampus area called CA2.

In an article titled "Coffee for your thoughts: New study suggests caffeine can help learning, memory"[13] from the Columbia Chronicle, Dudek discussed her work on the CA2 region of the hippocampus.