Sergei Gennadievich Alifirenko (Russian: Серге́й Геннадиевич Алифиренко, born 21 January 1959) is a Russian pistol shooter, originally from Armenia, specializing in the 25 m Rapid Fire Pistol event.

Since the rules for the event changed on 1 January 2005, Alifirenko has been most successful in his adaptation to them.

After a bronze medal at the 2006 ISSF World Shooting Championships and a gold medal at the pre-Olympic World Cup competition in Beijing in April 2008, it was a setback for the Russian team when he had to withdraw from the Olympics due to eye illness.

[1] In October 2008 Alifirenko was suspended for 2 years after he failed a drug test for dexamethasone doping.

This biographical article relating to sport shooting in Russia is a stub.