Sergio Antonio D'Antoni (born 10 December 1946 in Caltanissetta) is an Italian politician, syndicalist and sports manager, current President of CONI Sicilia.

He joined the Italian Confederation of Workers' Trade Unions (CISL) in the early 1970s, becoming finally its General Secretary in 1991.

He remained leader of the CISL until 2000, furthermore he has been member of the National Council for Economics and Labour (CNEL) from 1991 to 1999.

In 2002 he joined the Union of Christian and Centre Democrats, becoming its Deputy Secretary; but, in 2004, he left the UDC to join Democracy is Freedom – The Daisy, led by Francesco Rutelli.

In the 2006 Italian general election he was re-elected to the Chamber of Deputies and he became Vice-Minister for Economic Development in the Prodi II Cabinet.