He also appeared in the stage debut of Léo written by Rosa Labordé for which he received a Dora Award nomination in 2006.
Di Zio is best known for playing Michelangelo Scarlatti, nicknamed "Spike", on the CTV police drama Flashpoint.
After making his debut in the 1995 film Senior Trip, Di Zio appeared in a string of telepics including The Wall, Major Crime, Freak City, Rembrandt: Fathers & Sons, and RFK.
Additionally, he guest starred on other Canadian series, such as Murdoch Mysteries, Republic of Doyle, and even played "Ripper" on Stoked for 11 episodes.
Film appearances include Ron Howard's Cinderella Man, Boondock Saints, Flash of Genius, and the Independent Spirit Awards winning The Lookout, playing Deputy Ted.