While still active in MLB, Escalona stood 6 feet 0 inches (1.83 m) tall, weighing 215 pounds (98 kg), according to sources.

[1] Due to a need for an additional pitcher in the bullpen, the Phillies purchased Escalona's contract from Reading and promoted him to the Major League club on May 16, 2009.

[2] Escalona made his major league debut on May 17, 2009, pitching a scoreless inning and striking out one batter against the Washington Nationals.

[4] On January 10, 2011, Escalona was acquired by the Houston Astros, in exchange for minor league second baseman Albert Cartwright after being designated for assignment by the Phillies a few days prior.

On March 24, 2012, the Astros announced that Escalona would undergo Tommy John surgery due to a torn ulnar collateral ligament in his left elbow, and will be out for the 2012 season.