He has worked with some of Latin music's most popular artists starting with Marc Anthony, DLG, Jennifer Lopez, Tito Nieves, Víctor Manuelle, Frankie Negrón, Johnny Rivera, Ray Sepúlveda, Tito Puente, Thalia, Orquesta de la Luz, Ivy Queen, Celia Cruz, La India, Jerry Rivera, Bacilos, Leslie Grace, Toby Love, Cheo Feliciano, Prince Royce, Liz Elias, Indy Flow, among others.

George later became the main visionary behind the New York-based Latin label RMM Records & Video, between 1988 and 1995, arranging, producing, and directing dozens of recordings for that label, working with artists like Jose Alberto 'El Canario', Johnny Rivera, Domingo Quinones, Tony Vega, Ray Sepulveda, Cheo Feliciano, Celia Cruz, La India and others.

He also produced and sessioned in recordings outside of RMM during this period, including albums with Nestor Sanchez, Junior Gonzalez, Africando and Los Hermanos Colon, as well as arranging several hit songs, including his arrangement on the hit track "Solo" for Luis Enrique on his 1989 album "Mi Mundo".

At the end of 2009, La India signed with Top Stop Music, having her first single released in early 2010, "Estupida" which quickly reached number one on the US Billboard Tropical Songs chart.

At the 11th Latin Grammy Awards, George received his second Latin Grammy for Producer of the Year, for his work on "Corazón Sin Cara", "Tu y Yo" and "Stand By Me" by Prince Royce, "Estúpida", "Si Él Te Habla De Mi", "Smile" and "Te Vas a Arrepentir" by La India.

At the 14th Latin Grammy Awards, George took home a trio of Latin Grammys for Producer of the Year, Producer of Marc Anthony's Record of the Year "Vivir Mi Vida" and Best Salsa Album for "Sergio George Presents Salsa Giants."