Sergio Alejandro Santana Piedra (born 10 August 1979) is a Mexican former professional footballer and assistant manager of Liga de Expansión MX club Oaxaca.

Santana stated his desire to leave Chivas following the arrival of Carlos Ochoa, and several months later, it was announced that he would go to Deportivo Toluca F.C.

On June 17, 2009, during the Mexican Football draft in Cancun, the Monterrey announced that Santana was to join their squad.

On 24 August 2016, Santana played his last game against Club América in a group stage match of the 2016 Copa MX Apertura.

Santana represented the Mexico national team in a game against China on 16 April 2008, making his seventh appearance since Ricardo LaVolpe called him for El Tri.