In the 1989–90 season, Scariolo's Scavolini was able of winning another Italian league title, defeating Pallacanestro Varese 3–1 in the national finals.

However, Pesaro succeeded in reaching the European Champions Cup Final Four, but it was defeated 93–84 in the semi-finals by KK Split, which then won the trophy.

[16] However, in the following season, Real was defeated 3–0 by Barcelona in the national finals, while in 2001–02, it was ousted in the quarterfinals by CB Estudiantes and Scariolo was sacked.

From 2003 to 2008, Sergio Scariolo was the head coach of the Spanish club Unicaja Málaga, which, under his tenure and thanks to the leadership of Jorge Garbajosa, lived its so-called "golden age".

In the following season, Olimpia failed in reaching EuroLeague's Top16 and was once again defeated 4–3 by Siena in the playoffs' quarterfinals and Scariolo resigned from his post.

On July 25, 2018, Scariolo was hired by the Toronto Raptors as an assistant coach,[21] aiding them to win their first NBA championship.

[23] On 18 June 2021, Scariolo signed a three-year deal with Virtus Bologna, of the Italian Lega Basket Serie A (LBA).

[25] Moreover, after having ousted Lietkabelis, Ulm and Valencia in the first three rounds of the playoffs, on 11 May 2022, Virtus defeated Frutti Extra Bursaspor by 80–67 at the Segafredo Arena, winning its first EuroCup and qualifying for the EuroLeague after 14 years.

[26] However, despite having ended the regular season at the first place and having ousted 3–0 both Pesaro and Tortona in the first two rounds of playoffs, Virtus was defeated 4–2 in the national finals by Olimpia Milan.

[27] On 29 September 2022, after having ousted Olimpia Milano in the semifinals, Virtus won its third Supercup, defeating 72–69 Banco di Sardegna Sassari and achieving a back-to-back, following the 2021 trophy.

In June, after having ousted 3–0 both Brindisi and Tortona, Virtus was defeated 4–3 by Olimpia Milan in the national finals, following a series which was widely regarded among the best in the latest years of Italian basketball.

[35] Sergio Scariolo appeared in the Netflix film Hustle, produced by LeBron James and Adam Sandler, who was the co-star along with Juancho Hernangómez, which was released on 8 June 2022.