He succeeded his father John VI on the Neapolitan throne in 1122 at a time when Roger II of Sicily was rising rapidly in power.
When Roger succeeded as duke of Apulia in 1127 and was crowned king in 1130, the fate of Naples hinged on Sergius' relations with the Sicilian court.
According to the chronicler Alexander of Telese, Naples "which, since Roman times, had hardly ever been conquered by the sword now submitted to Roger on the strength of a mere report."
Yet according to the historian and rebel sympathiser Falco of Benevento, Sergius and the Neapolitans did not relent, "preferring to die of hunger than to bare their necks to the power of an evil King."
Roger finally absorbed the Duchy of Naples into his new kingdom in 1139, when the pope, Innocent II, and the Neapolitan nobility acknowledged the young Alfonso of Hauteville as duke.