[1] At the 2007 AIBA World Boxing Championships, he beat Argenis Casimiro Núñez in the quarter-finals to win a bronze medal, but was unable to progress any further, losing to Matvey Korobov in the semi-final.

Derevyanchenko took part in the 2009 AIBA World Boxing Championships, where he reached the quarter-finals but fell short against Vijender Singh.

[4] Derevyanchenko headlined his first televised card in August 2015, facing off against Elvin Ayala in an eight-round bout aired on ShoBox,[5] winning by a wide unanimous decision, improving his record to 6–0.

Soliman was dropped a further two times in the second-round, causing the referee to wave off the fight, giving Derevyanchenko the win by technical knockout (TKO).

[6] The IBF ordered an eliminator between Derevyanchenko and Tureano Johnson, with the winner becoming the mandatory challenger to the unified middleweight champion Gennady Golovkin.

[8] 27 October 2018, he fought Daniel Jacobs for the vacant IBF middleweight title at the Hulu Theater, New York.

Winning by unanimous decision, Derevyanchenko became the mandatory challenger for unified middleweight champion Canelo Álvarez.

[9] On 5 October 2019, he faced Gennady Golovkin for the vacant IBF and IBO middleweight titles at Madison Square Garden, New York City.

The knockdown appeared to spur Derevyanchenko into action as he began to answer Golovkin's punches with his own shots for the remainder of the round.

Golovkin was the aggressor for the majority of the fourth round, having partial success, with Derevyanchenko picking his moments to fire back with two and three punch combinations and continuing to work the body.

At the beginning of the fifth round, the ringside doctor gave the cut above Derevyanchenko's right-eye a close examination before the action resumed.

[14] During the bout, Derevyanchenko suffered a torn left bicep in the fourth round, rendering him to only one fully functioning boxing arm.