In 1997, he placed second in a contest for high-school students presenting their scientific works, organized by the Junior Academy of Sciences of Ukraine.

In January 1999, he appeared on Radio Ternopil 106.1 FM under the nickname Siryi ("Grey" in Ukrainian, a word play on his first name Serhiy).

Disappointed with studying, Prytula tried a number of jobs in London: from a builder and loader to a waiter and cook's helper.

[7] Between 2006 and 2009, Prytula was a regular participant of the standup TV show Real Comedy, where he cultivated a sarcastic image from sharply addressing Ukrainian celebrities.

[18] In February 2022, Prytula and supporters started to collect signatures for the establishment of his new political party, called 24 August.

On August 18, 2022 the Finnish microsatellite manufacturer ICEYE signed a $17M contract with the Serhiy Prytula Charity Foundation to give the Armed Forces of Ukraine full access to one of its satellites.

[2][24][3] This provided Armed Forces of Ukraine with on-demand access to all-weather high-resolution reconnaissance imagery through a synthetic aperture radar (SAR) for use in operational planning.

[25] On November 2, 2022, the Serhiy Prytula Charity Foundation organized a $5.5M "Grab them all" crowdfunding appeal to buy 50 used ex-British military FV103 Spartan APCs (armored personnel carriers) for the Ukraine army, a fast small- tracked vehicle ideal for muddy and snowy conditions at the frontline in the South of Ukraine.