The regular season ran from October 9, 2005 to May 2006, 18 teams played 34 games each.

The top 8 teams made the play-offs whilst the lowest ranked team, Viola Reggio Calabria and the bankrupt club BT Roseto, were relegated to the Legadue.

Benetton Treviso won their second title by winning the playoff finals series against Climamio Bologna.

BT Roseto team went bankrupt after the season, therefore Air Avellino was spared relegation.

Quarterfinals Semifinals Finals Statistics are for the regular season.