Serotonin reuptake inhibitor

For example, cocaine, which non-selectively inhibits the reuptake of serotonin, norepinephrine, and dopamine, is an SRI but not an SSRI.

Less often, SRIs are also used to treat a variety of other medical conditions including neuropathic pain and fibromyalgia (e.g., duloxetine, milnacipran), and premature ejaculation (e.g., dapoxetine) as well as for dieting (e.g., sibutramine).

A closely related type of drug is a serotonin releasing agent (SRA), an example of which is fenfluramine.

Note that only SRIs selective for the SERT over the other monoamine transporters (MATs) are listed below.

For a list of SRIs that act at multiple MATs, see other monoamine reuptake inhibitor pages such as SNRI and SNDRI.