Serpil İskenderoğlu (born July 15, 1982) is a Turkish handballer in the field player position.

SK in Istanbul before she transferred to İzmir Büyükşehir Belediyespor.

[3] She was the member of the national team that won the silver medal at the 2009 Mediterranean Games in Pescara, Italy.

[6] İskenderoğlu became the second most scorer player with 45 goals in six matches at the Group 4 2012 European Women's Handball Championship qualification.

In 2017, she won the silver medal with the national team at the Islamic Solidarity Games in Baku, Azerbaycan.