It contains a single species, Serrulatocereus serruliflorus,[3] endemic to northwestern and central Haiti.

[2] Serrulatocereus serruliflorus grows tree-like with sparse to richly branched, upright shoots and reaches heights of up to 4 meters.

The egg-shaped fruits are yellow gree, up to 9-11 centimeters long, and 3.5-6 cm wide.

[4] Plants are found growing on limestone hills of northwestern and central Hati.

[7] As of October 2023[update], C. ayisyen is considered by Plants of the World Online to be a synonym of Serrulatocereus serruliflorus.