Sesto al Reghena (Friulian: Siest) is a comune (municipality) in the Regional decentralization entity of Pordenone, in the Italian region of Friuli-Venezia Giulia, located in the lower Friulian-Venetian plain about 80 kilometres (50 mi) northwest of Trieste and about 20 kilometres (12 mi) southeast of Pordenone.

Sesto al Reghena borders the following municipalities: Chions, Cinto Caomaggiore, Cordovado, Gruaro, Morsano al Tagliamento, San Vito al Tagliamento.

It is one of I Borghi più belli d'Italia ("The most beautiful villages of Italy").

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