[1] The character of Brundle was played by Daniel Okulitch in Howard Shore's 2008 opera The Fly in its premiere at the Théâtre du Châtelet in Paris.

Brundle dedicated his life to his invention, and adopted personality traits similar to Albert Einstein, such as owning 5 pairs of the same set of clothing to save mental energy deciding what to wear.

Brundle attended a convention hosted by Anton Bartok (who would eventually become the main antagonist in the sequel), where he met Particle Magazine journalist, Veronica Quaife.

Brundle convinced Veronica to allow him to demonstrate his newly created "telepods" to her, gaining her intrigue when he stated that it would "change the world".

Drunken and depressed, Brundle recklessly performs the telepod's human testing on himself to deprive Veronica of witnessing his miracle of science.

To find a willing test subject, Brundle goes to a bar and enters an arm-wrestling competition with a man in exchange for his girlfriend, Tawny.

Brundle uses his newfound superhuman strength to snap the man's arm and spends the rest of the night engaging in sexual escapades with Tawny.

Brundle becomes increasingly overwhelmed by the shock and horror of his mutation and begins finding the humour of his degeneration, including his ability to stick to walls, while still searching for a cure for his condition all the same, eventually sending Ronnie away out of fear that his fly instincts will cause him to hurt her.

As the Brundlefly-telepod hybrid exits the receiving pod, it moves the shotgun Veronica was holding to his head, pleading for her to put him out of his misery.

[4][5] Before Goldblum was cast, many actors were considered for the role of Seth Brundle, including Richard Dreyfuss, John Malkovich, Mel Gibson and Michael Keaton.

The film was released in the middle of the AIDS outbreak in the United States, and the paranoia surrounding the disease and its effects, primarily on the gay community.

[26][27][28][29][30][31][32][33][34][35] Seth Brundle has become an iconic part of popular culture, referenced in many television shows and songs, as well as being recognised as one of Jeff Goldblum's best and most notable roles.

[43][44] Brundle was parodied on Saturday Night Live by Jim Carrey as 2020 presidential candidate Joe Biden in a reference to the fly that had landed on Vice President Mike Pence's head during the 2020 Vice-Presidential Debate.