Stoltz's character in this sequel is the adult son of Veronica Quaife and Seth Brundle, a scientist who became a human-fly hybrid as a result of an experiment gone awry, played by Jeff Goldblum in the 1986 remake.

Anton Bartok, the owner of the company that financed Seth Brundle's teleportation experiments, adopts the child and names him Martin.

When Martin is uneasy about the proposition, Bartok shows him Veronica Quaife's videotapes, which documented Seth Brundle's progress with the Telepods.

Seeing his father describe how the Telepods ostensibly improved and energized his body, Martin accepts Bartok's proposal.

Martin reconciles with Beth and arrives at his father's revelation and realizes the Telepods' computer needs to analyze living flesh.

Inside the dog's former enclosure, the Bartok creature crawls towards a food bowl filled with slops, and sees a single housefly sitting on its edge.

Mick Garris was hired to write and direct The Fly II and wrote multiple drafts of the film before losing patience with the production and joining Critters 2 due to liking the script and New Line Cinema offering him creative input.

[4] In an October 2020 interview with Entertainment Weekly, Garris stated: My exec on the project was Scott Rudin, who later became one of the best and most tasteful of producers.

Producer Stuart Cornfeld and I wanted to do something smart and adult in the realm of the brilliant Cronenberg movie that preceded it, and Scott was completely on board with us.

But Leonard Goldberg, producer of The Love Boat and other such TV shows, was inducted as the studio chief at Fox, and he wanted a teenage monster movie.

[5]Ken and Jim Wheat were tasked with rewriting Mick Garris's draft of the screenplay after Fox turned down the duo's proposal for After Midnight[6] The Wheat's described the initial draft of the film as "broad" and attempted to refocus the film but were unable to do so due to Fox's rushed schedule as well as receiving notes from eight different people that were oftentimes in conflict with each other.

[21] David Hughes from Empire awarded the film 3/5 stars, writing, "Whilst this fly is not as tightly scripted or keenly directed as its parent, it does have pace, breathless tension and the sort of gross-out effects that rules out kebabs for some time after the credits have rolled.

"[22] Ryan Lambie of Den of Geek wrote that while the film "wasn't particularly clever, ... as an exercise in pure, claret-stained entertainment, it deserves far more credit than it frequently receives".

[7] In July 1993, it was reported that development had begun on The Fly III with Richard Jefferies writing the screenplay that would feature the return of Geena Davis' character Veronica "Ronnie" Quaife for Brooksfilms and 20th Century Fox.

[23] According to Mel Brooks, Davis was the one who initiated the project including developing the story and serving as a producer with production slated to begin in Fall of that year.

Beginning in March 2015, IDW Publishing released a five-issue comic book miniseries titled The Fly: Outbreak, written by Brandon Seifert.