After receiving his M.D., Seong continued his education at Seoul National University College of Medicine and was awarded Doctor of Philosophy in both Immunology and Microbiology in 1995.
In 2012, he became the Associate Dean for Planning of Seoul National University College of Medicine and since his appointment in 2013 he has served as the Director of Wide River Institute of Immunology.
Currently, Seong serves as Associate Dean for Graduate Study and Professor of Seoul National University College of Medicine, as well as Editor in Chief of World Journal of Immunology.
In addition, the DAMPs model suggests that the early immune system evolved from an ancient damage response initiation pathway directed by the presence of hyppos.
[7] In studying nuclear factor-κB dependent gene expression Seong found strong evidence that apolipoproteins function as a hyppo-quencher.
When exposed to high hyppo levels, cells with apolipoproteins did not initiate immune responses evidencing their role as a hyppo-quencher.
In pathological conditions and cases of cell damage the concentration of exposed hyppos in tissue microenvironment is too great to be resolved by activity of quenchers.