[2] In 1916, she and her husband moved to Jolo (Sulu), as the first Christian doctors to introduce Western medicine in a predominantly Muslim area.

[4] In a 1917 report by the United States Department of War, Severina de Orosa was listed as an assistant resident physician at the public hospital of Sulu.

[3] In 1926, Severina was appointed physician for the city schools of Manila and later became the chief of the maternity and children's hospital in Bacolod.

[2] Orosa was also an active writer in Spanish, Tagalog and English; she frequently authored articles to the Philippines Herald and was nicknamed the “First Filipino Columnist” by the paper's editor, Modesto Farolan.

[2] A marker in her honor was unveiled on December 20, 1990, at the Luna-Orosa Building in Ermita, Manila.