[citation needed] The Fernando Calderon Hall is the main building of UP College of Medicine students.

Named after the first Filipino dean of the college, the building was transferred from Bonifacio Drive to its current location in Pedro Gil Street, Manila in 1910.

[2] The Calderon Hall and the University of the Philippines College of Medicine was the only UP unit that was open and functional during the height of the Second World War, to provide medical services needed during that time.

Its medicine proper (Learning Units III to VII) is designed with an Organ Systems Integration (OSI) curriculum beginning in 2009.

Only 50 applicants/Direct Entrants (25 males and 25 females) will finally be admitted into the program following a selection process which includes an interview.

[9] Only applicants who have obtained their baccalaureate degree (Bachelor in Science or Arts) by the end of a Philippine school year are eligible.

The applicant must have a valid National Medical Admission Test (NMAT) score not lower than 90 percentile.

The applicants would then be trimmed down by a rigorous selection process to the final 150 Lateral Entrants for LU III.