The film centers on Paul Lorenz, a "concerned citizen" alarmed at the spread of venereal diseases such as syphilis and gonorrhea.

However, at a New York City burlesque show, several protagonists are more intent on engagement in sexual pleasure, regardless of the subsequent costs.

They include Paul's own son Tom, burlesque dancer Sheila Wayne (who has syphilis), and two secretaries, lesbian Peggy and Betty, whom she is trying to seduce.

Millicent won a beauty contest in her hometown, which led her to New York, but she contracted syphilis after a "casting couch" sexual encounter.

Millicent's physician, Dr. Hampton, tells her that her condition can be cured, but only after slow and painstaking treatment; she should reject quick "quack" pseudo-cures.