Along with Primero, Segundo, Tercero, Cuarto, and Quinto, Sexto is one of the municipality's six core urban barrios.

[5] At 2.5 kilometres (1.6 mi) northeast of Plaza Las Delicias were located the "Baños Termales de Quintana" (Quintana Thermal Baths)[note 1] as well as a quarry of white stone in this area.

[7] In terms of barrio-to-barrio boundaries, Sexto is bounded in the North by Portugués Urbano and Machuelo Abajo, in the South by Quinto, in the West by Segundo and Portugués Urbano, and in the East by Machuelo Abajo.

[9] The communities of La Cantera, Hoyo de Pepe, El Yeso, and Pueblito Nuevo are found here.

Barrio Sexto is home to the NRHP-listed old Spanish Military Hospital.