Seymour Horace Knox I (April 11, 1861 – May 17, 1915), was a businessman from Buffalo, New York, who made his fortune in five-and-dime stores.

[2] His father was James Horace Knox, a farmer married to Jane E. McBrier.

However, after the partners took a lunchtime walk, they returned at 1:30 to find the local factory workers had been let out at 1:00—with their paychecks.

[3] His second store, in Newark, New Jersey, was short lived, but his partnership thrived nonetheless.

He partnered with Frank to open the first Buffalo store, at 409 Main Street, on October 13, 1888.

[3] He formed another brief partnership with another friendly rival, Earle Perry Charlton, from 1889 to 1895, opening his Buffalo "S.H.

By the time of the 1911 incorporation of F. W. Woolworth Company, Knox was the second largest of six store operators with 98 U.S. and 13 Canadian locations.

[4] At his death, Seymour was Vice President of the Woolworth Co. and Chairman of the Board of the Marine Trust Co.

[2] After his death, his wife built a new mansion on Delaware Avenue for her and their children, designed by New York City architect C. P. H. Gilbert, known today as the Mrs. Seymour H. Knox House.