Seyppel is an unincorporated community in Crittenden County, Arkansas, United States.

[1] Highway 147 passes through Seyppel, and the Mississippi Levee borders the east side of the community.

A short distance east of the levee is Seyppel Landing, located directly on the Mississippi River.

At the time of his death in 1865, Burgett was the oldest citizen in Crittenden County.

James Cotton was known to have performed at a juke joint once located in Seyppel, and blues guitarist Hubert Sumlin accidentally fell through its window one evening while watching Howlin' Wolf perform.