Shahqoli Khan Zanganeh (Persian: شاه‌قلی‌خان زنگنه, died 1716), was a Kurdish nobleman, who served as the vizier of the Safavid king (shah) Sultan Husayn (r. 1694–1722) from 1707 to 1716.

One year later, a powerful and high-ranking aristocrat of the Turkoman Sahandlu tribe named Saru Khan Sahandlu, had 40 members of the Kurdish Zanganeh tribe killed, which made Shahqoli protest to shah Suleiman I, stating that Saru Khan had humiliated the name of his deceased father by doing so.

Suleiman forgave Saru Khan, due to the good relation they had.

The shah then appointed Shahqoli as the head of the royal bodyguard (qurchi-bashi), thus succeeding Saru Khan.

[5] Shahqoli had a son, also named Shaykh Ali Khan, who although did not reach the same height of power as his father and grandfather, still served in high-office under the Safavids.