[2] Through VPS Healthcare, his family office, he oversees an extensive investment portfolio including Burjeel Holdings, RPM, LifePharma, Lakeshore Hospital, Ziva, Keita, and Educare Institute.

He is on the board of directors of Kannur International Airport Ltd.[10] Vayalil contributed AED 5 million to the Emirates Red Crescent to join global relief efforts in supporting those affected by the devastating earthquakes that hit Turkey and Syria in 2023.

[11] In April 2014, Vayalil filed a petition in the Supreme Court of India in connection with non-resident Indian (NRI) voting rights.

The Court directed the Election Commission of India to explore the possibility for NRIs to cast their vote from their place of residence.

In October 2014, the commission submitted its report to the Court, recommending that NRIs be permitted to vote by proxy and e-postal ballot.