Sharky & George is set in the underwater city of Seacago, populated by various kinds of fish.

Sharky, the bigger fish, is a rather lazy pink shark with a huge nose, and wears a Humphrey Bogart-style fedora hat.

The two friends combat the mad plans of conquest of the many villains and gangs that are terrorizing Seacago, including Lefty Hook, Harry Flix, the three thugs: Nova, Scotia and Lox, the Piranhas, Fishy Ben Backstabber, Dr. Medusa (Dr. Jelly in English versions; mad scientist and self-proclaimed master of the world), Ray Manta and the electric Torpedo Rays, the Fish Fry Gang, and Red Lobster (Colonel Klaw in English versions; German commander of the army of Black Crab).

Sharky & George was also shown in Ireland on RTÉ Two, in France on Canal+, Antenne 2, FR3 and Canal J, in Serbia on RTV Politika, in Italy on Rai Uno, Rai Due and Telepace, in San Marino on San Marino RTV, in Malaysia on TV3, in Hungary on Magyar Televízió, in Poland on TVP1 (dubbed), in Singapore on Channel 5 and in Spain on TVE.

The show was broadcast in various Middle East TV networks in Arabic language, known as "Sharky wa George" Four VHS cassettes were released in the late '90s, but are now out of print.