Rege's work within the academia, to fight for the right of the Dalit student's rights, has been a testimony of her commitment to critical educational reform in India[6] An obituary described her as a "Phule-Ambedkarite Feminist Welder" who brought the "structural violence of caste and its linkages with sexuality and labour into the feminist discourse".

Her emphasis on relocating the central role of B. R. Ambedkar in the shaping of the modern nation state has ensured that the voice from the margins does not remain invisible opens up space for political contestation and dialogue in a public debate that is quickly being gentrified by the rhetoric of economic development and globalisation.

[8] One of Rege's major texts was the essay 'Interrogating the Thesis of 'Irrational Deification'', on popular Ambedkarism in the 1990s, was first published in the Economic & Political Weekly (v 43, n 7, 16 February 2008), and reprinted in the volume The Hunger of the Republic: Our Present in Retrospect, part of the India Since the 90s series published by Tulika Books.

In her last published work, Against the Madness of Manu,[9] she sought to centralise Ambedkar's role in the women's movement by invoking his ideological fight against Brahminical patriarchy, and how the caste system engenders graded violence against women.

Her particular focus on alternative history writing has given new life to the local and oral traditions of knowledge and cultural practice, by bringing them into public attention through translation projects that build archives of national memory.