She is known for her portrayal of Rosalie Aprile on the HBO series The Sopranos.
Angela has appeared in several films such as Cabaret Maxime, The Hungry Ghosts, Ghost Dog: The Way of the Samurai, On the Run, and Two Family House.
During the sixth season of The Sopranos, Angela was elevated from guest star to series regular for her character Rosalie Aprile, the widow of Jackie Aprile Sr., and is also a close friend of Carmela Soprano.
She also voiced Angie Pegorino in the 2008 video game Grand Theft Auto IV.
Angela is an instructor at the Lee Strasberg Theatre and Film Institute in Los Angeles.