The Sharzhenga (Russian: Шарженга, Шарженьга) is a river in Nyuksensky, Babushkinsky, and Nikolsky Districts of Vologda Oblast in Russia.

The river basin of the Sharzhenga comprises the northwestern part of Nikolsky District and is located in the Northern Ridge chain of hills.

The river flows south, enters Babushkinsky District, and turns northeast.

Downstream from the village of Zelentsovo the valley of the Sharzhenga is almost continuously populated, and the forests on the river banks have been cut.

The mouth of the Sharzhenga is downstream of the village of Kalinino, between the town of Nikolsk and the selo of Kichmengsky Gorodok.