[9] Under his presidency, Mirziyoyev implemented a range of liberal reforms[example needed] in Uzbekistan’s political and economic system by attracting foreign investment, improving relations with neighboring Central Asian countries, as well as release of political prisoners that was notably accompanied by closure of the infamous Jaslyk Prison in 2019.

O‘rinbek Yoqubov, a cousin of Miromon, being a veteran of World War II, became a Hero of the Soviet Union in April 1944.

In early 1990, he was elected as a deputy of the Supreme Soviet of the Uzbek SSR's last legislative body before the independence of Uzbekistan in 1991.

They signed several agreements, including one deal in which Uzbekistan was to send 300 tons of Uzbek uranium ore to South Korea every year from 2010 to 2014.

The deal bypasses U.S. companies that acted previously as middlemen for South Korean imports of Uzbek uranium ore. Han also met with President Islam Karimov and parliament speaker Erkin Xalilov.

Han and Mirziyoyev boosted cooperation in the energy, agriculture, construction, architecture, and information technology sectors.

The 2016 harvest, when Mirziyoyev was acting president and retained control over cotton production, continued to be defined by mass involuntary mobilization of workers under threat of penalty."

The report states that during a 2015 conference call with local authorities and farmers, Mirziyoyev said “Go to the homes of farmers in debt, who can't repay their credit, take their cars, livestock, and if there are none, take the slate from their roofs!”[26] On 24 October 2021, Uzbekistan's Central Election Commission announced that Mirziyoyev received 80.1 percent of the vote and will serve a second five-year term.

[27] A member of the Samarkand clan, he was considered to be one of the leading potential successors to Islam Karimov as President of Uzbekistan.

Mirziyoyev was reported to have friendly relations with Karimov's wife, Tatyana Karimova, and National Security Council chairman Rustam Inoyatov.

[28] After the death of Karimov was announced on 2 September 2016, Mirziyoyev was appointed as head of the committee organizing the funeral of the President.

He started to settle a long-running border dispute with Kyrgyzstan, and regular flights between the capitals of Uzbekistan and Tajikistan were set to resume in January 2017 for the first time since 1992.

[31][32] The electoral commission announced on 16 September that Mirziyoyev would stand in the December 2016 presidential election as the candidate of the Liberal Democratic Party.

[33] Mirziyoyev won the election, held on 4 December 2016, with 88.6% of the vote according to official results, defeating three minor candidates.

The Organization for Security and Co-operation in Europe said the election lacked "a genuine choice," pointing to instances of ballot box stuffing and proxy voting.

[35] Mirziyoyev was sworn in as president on 14 December, vowing to "continue the work of my dear teacher, the great statesman Islam Karimov", while also promising "many changes in the cabinet".

[39][40] However, the German Federal Ministry for Economic Cooperation and Development noted that "The people of Uzbekistan play no part in political decision-making processes.

So far, no parliamentary or presidential election held in the post-Soviet era has been considered as either free or fair by the international community...

Uzbekistan was practically under international isolation after the Andijan massacre in 2005 and Karimov rarely travelled outside of Central Asia and other CIS states.

At the different occasions, he met the presidents of Iran, Azerbaijan, Afghanistan, Tajikistan, Bulgaria, Belarus and the King of Spain.

[64] Mirziyoyev has also taken an important role in Afghanistan by offering to host peace talks between the government and the Taliban since March 2018.

During the week of 6–10 August 2018, a Taliban delegation visited Tashkent, at the request of Mirziyoyev, to discuss issues including transport, power and peace in Afghanistan.

[72] Since coming to power, Mirziyoyev has built a new residence for himself in Qibray District, which includes his own presidential highway,[73] and an interior that is decorated with Argentinian marble slabs and Swarovski crystals.

Two sources estimated the cost of the development at several hundred million dollars, though only a handful of publicly available official documents make reference to the compound and the adjacent reservoir, which were largely completed by 2019.