Earlier films included Soldier's Girl, The Faculty, In & Out,[6] The Cooler, Outside Providence,[7] Anywhere but Here, John Q, A Guy Thing, and 2006's Alpha Dog.

Hatosy has appeared in such television shows as SEAL Team, CSI: Crime Scene Investigation, The Twilight Zone, Felicity, Six Feet Under, ER, Law & Order, Numb3rs, My Name Is Earl, Hawaii Five-0,[9] Criminal Minds,[10] Fear the Walking Dead, Flaked, and Bosch.

[12] Other roles were serial killer Boyd Fowler on the Showtime television series Dexter[13][a] and police officer Terry McCandless in Reckless.

[18] He also made an appearance in Justin Timberlake's music video for his single "What Goes Around... Comes Around", alongside Scarlett Johansson as the drunk love interest.

In 2005, Hatosy performed opposite Al Pacino in Lyle Kessler's Orphans, at the Greenway Court Theatre in Los Angeles.