The series is created and showrun by R. Scott Gemmill who is also an executive producer alongside Noah Wyle, John Wells, Erin Jontow, Simran Baidwan, and Michael Hissrich.

[10] On August 27, 2024, it was reported that the estate of ER creator Michael Crichton, represented by his widow Sherri, had sued Warner Bros. Television, Wells, Wyle, and Gemmill—all of whom had been involved in the earlier series—over breach of contract, claiming that The Pitt was a reworking of a planned sequel to ER that the estate had not approved, and that Crichton should be credited as creator of The Pitt.

[1] On July 12, 2024, Tracy Ifeachor, Patrick Ball, Supriya Ganesh, Fiona Dourif, Taylor Dearden, Isa Briones, Gerran Howell, Shabana Azeez, and Katherine LaNasa joined the cast as series regulars.

[13] On August 14, 2024, Shawn Hatosy, Michael Hyatt, Jalen Thomas Brooks, Brandon Mendez Homer, Kristin Villanueva, Amielynn Abellera, Alexandra Metz, Krystel V. McNeil, and Deepti Gupta were cast in recurring capacities.

The website's critics consensus reads, "Setting the trials and tribulations of hospital life on a timer, The Pitt combines multiple tried-and-true formulas to create a bracingly fresh medical drama.