Waldron is best known for her roles as Becky O'Shea in the 1994 sports comedy film Little Giants and as Bonnie Stiles on CBS television series Ladies Man.
Waldron was featured in a string of commercial roles before landing the part of Becky "Icebox" O'Shea, the only girl on a pee-wee football team, in the movie Little Giants.
After starring in Little Giants, Waldron went on to play Michael Douglas' daughter in the movie The American President.
She then guest-starred on the series Malony in which she played the dramatic role of a teen who had witnessed a murder.
Waldron was nominated for Best Performance in a TV comedy series, Supporting Young Actress category from the Twenty-first Annual Young Artist Awards for 1998–1999 for her role in Ladies Man.