His mother was diagnosed with multiple sclerosis and as a result the Skov family moved to Guadalajara, Jalisco for its mild climate and affordable healthcare.

Shayne and his brother Patrick first began playing football in a team named Carneros de Guadalajara.

He participated in the 2009 U.S. Army All-American Bowl in San Antonio, Texas, where he recorded seven tackles including three for loss.

As a sophomore, he went on to being named a conference honorable mention after recording 84 tackles (50 solo), including 10.5 for a loss, 7.5 sacks, two forced fumbles and five pass break ups.

His season was highlighted by a 12 tackle, 3 sack performance against Virginia Tech in the 2011 Orange Bowl.

In his junior season, he suffered a season-ending injury against Arizona in Week 3,[3] but allowed him to be granted a medical redshirt.

In 2012, after missing the season opener against San Jose State for a DUI during the off-season,[4] he started in 13 games, recording 81 tackles, including nine tackles for loss and 2.5 sacks and was named a conference honorable mention.