American graduate student Randi Wallace (Kate Hodge) travels to Britain to study mythology with Prof. Ian Matheson (Neil Dickson).

Randi's curse draws the attention of various supernatural creatures: another werewolf, spirit possession, succubus, a possessed bookstore, a bogeyman, an evil carnival, a Guy Fawkes spirit, a killer horseman, in a small town, zombies who ultimately confront Randi in her werewolf form (Diane Youdale).

Kate Hodge – As a graduate student Randi Wallace, who after surviving a werewolf attack, fears what she will become every time there's a full moon.

[2] Midway through the first season, HTV pulled their financial backing, and the lower budget forced production to move to Los Angeles for the final six episodes.

The series was retitled Love and Curses; Neil Dickson's character was dismissed from his position as a British professor and moved to L.A. to become the host of a talk show investigating the paranormal (explained by the success of one of his books after it was issued with a trashy mass market title).

It was announced on November 18, 2009 that all 20 episodes of She-Wolf of London/Love and Curses would be released in a complete series box set from Universal Studios Home Entertainment.