The mid-tempo R&B record was written by Brown, Jean Baptiste, Ryan Buendia, Kevin McCall and Jason Boyd, and was produced by Free School.

Musically, "She Ain't You" samples the remixed version of SWV's "Right Here" (1993), as well as Michael Jackson's "Human Nature" (1983).

"She Ain't You" received positive reviews from music critics, that praised Brown's lyrical and vocal performance, as well as its production.

The accompanying music video was directed by Colin Tilley and features Brown paying tribute to Michael Jackson.

[8] "She Ain't You" contains a portion of a remixed version of SWV's "Right Here" (1993), which in turn samples Michael Jackson's "Human Nature" (1982).

"[10] According to Scott Shetler of AOL Music, on the song, "an hopeful Brown sings about missing his ex-girlfriend, while living a new relationship.

"[13] Brown then appears in a 1980s-styled white suit and a black fedora,[13] performing choreography with male and female dancers against a wall of neon lights.

[11] Anthony Osei of Complex magazine wrote, "If anyone can do a great Michael Jackson tribute, it's Chris Brown.

"[14] A writer of DesiHits wrote that the video brought the "same magic" from his tribute to Jackson at the 2010 BET Awards, and added that it included "great lighting and even better choreography.

Busta Rhymes later appeared from a brightly lit cube flanked by dancers in eerie, transparent masks illuminated by blinking lights.

[20] On July 15, 2011, Brown performed "She Ain't You" in front of an audience of 18,000 people at the Rockefeller Plaza in New York City as part of Today concert series.

[22] Sarah Rodman of The Boston Globe wrote that the song "is totally shameless and completely effective" as it "derives much of its charm from a hefty sample of Michael Jackson's 'Human Nature'".

"[24] While reviewing the album, Sean Fennessey of The Washington Post wrote that "a more appropriate application appears on 'She Ain’t You', which interpolates Michael Jackson's 'Human Nature'.

[27] In the issue dated April 2, 2011, "She Ain't You" debuted at number 75 on the US Hot R&B/Hip Hop Songs chart.

[33] The song was certified gold by the Australian Recording Industry Association (ARIA), denoting sales of 35,000 copies.