[3] She has appeared in the drama serials Balila, Maray Thay Jin K Liye, Tanhaiyaan and Ankahi, as well as the show Uncle Sargam.
The show aired only few episodes and it got cancelled later[8][9] but Sheikh already got noticed by that time and signed in drama serial Ankahi written by Haseena Moin and directed by Syed Mohsin Ali and Shoaib Mansoor.
She played the role of Sana Murad an ambitious and level headed girl from middle-class family.
[11] After the success of Ankahi, Sheikh again collaborated with Hassena Moin in her next drama serial Tanhaiyaan directed by Shahzad Kalil.
He wanted Hina Durrani to be the lead heroine in Henna after meeting her in India during her visit with her mother Noor Jehan in 1982 but she refused.
I wanted to branch out into something more diverse, more challenging,"[7] After 27 years of Tanhaiyaan drama serial, a sequel named Olper's Tanhaiyan: Naye Silsilay was aired in late 2012.
Six of the 16 original cast members reprised their roles but Sheikh refused the offer since she has quit acting.
[23] During an interview, Haseena Moin said about Sheikh's refusal of the offer to be a part of Tanhaiyan Naye Silsilay that "My guess is that as she had created an image in the past serial with her looks and young age, she didn’t want to spoil it.
"[7] In November 2005, she along with her husband worked with FAME, a welfare organisation to help victims of 8 October 2005 earthquake in Northern Pakistan.