She moved with her parents in 1945 to Manhattan, New York City, where she worked at a dime store on 125th Street, across from the Apollo Theater.
(1947), Sepia Cinderella (1947, co-starring with Billy Daniels), and Miracle in Harlem (1948) giving impressive performances in all of them.
[2] She also appeared in the Broadway stage productions Lost in the Stars and Finian's Rainbow, which were both long-running.
Sheila Guyse was popular in the 1940s and 1950s, and graced many covers of publications such as Jet, Ebony, and Our World.
The couple was featured in the article "Negro Women with White Husbands" in the February 1952 issue of Jet.
[1] Shelia Guyse's health played a very important role in her career as a performer and entertainer.
In 1953, she was diagnosed with stomach ulcers a day after she had accepted a role in the Broadway stage production Mile High.