The Sheksna (Russian: Шексна́) is a river in the Belozersky, Kirillovsky, Sheksninsky, and Cherepovetsky districts of Vologda Oblast in Russia.

It joins the northern part of the Rybinsk Reservoir of the Volga near the city of Cherepovets.

Previously, the length of the Sheksna was some 400 kilometers (250 mi), and the mouth of the river was located in the city of Rybinsk, Yaroslavl Oblast.

The river basin of the Sheksna comprises vast areas in the west and in the northwest of Vologda Oblast, including parts of Vytegorsky, Vashkinsky, Kirillovsky, Belozersky, Sheksninsky, and Cherepovetsky Districts, as well as minor areas in Kargopolsky District of Arkhangelsk Oblast.

This area includes the towns of Kirillov and Belozersk, as well as the urban-type settlement of Chyobsara and the selo of Lipin Bor, the administrative center of Vashkinsky District.