Sheldon is an unincorporated community and census-designated place (CDP) in Beaufort County, South Carolina, United States.

Several hunt clubs and gated communities are located in the area.

The Pocosobo Town was listed on the National Register of Historic Places in 1994.

Sheldon is located approximately halfway between Beaufort and Yemassee and just east of Interstate 95 in the heart of the Lowcountry region.

This South Carolina state location article is a stub.