He is recognized as one of the leading authorities on micro nutrition, human physiology and the impact of diet and lifestyle upon health and disease and was known for his ability to customize treatments for his patients.
As a practicing internist, Hendler applied his encyclopedic knowledge of biochemistry to address the most profound mysteries of human metabolism to advance therapeutic options in patient care.
Among his many achievements was the world's first description and biochemical characterization of an entirely new human disease, Elastoderma,[2] described by Hendler and colleagues in the New England Journal of Medicine in 1985.
Hendler helped found the Medical School at Universidad Autónoma de Baja California, Tijuana, and chaired their first Department of Biochemistry.
He was also the founding editor-in-chief of the International Journal of Medicinal Food[9] Hendler was an accomplished musician and concert-level jazz trumpet player.