The Sheraton Fallsview is situated directly across from Niagara Falls in the heart of the tourist district.

The Sheraton is the cornerstone of Falls Avenue Resort which includes an indoor walkway from the hotel to attractions and dining options on complex that include the Fallsview Indoor Waterpark, Hershey Store, Rainforest Cafe, Hard Rock Cafe, Adventure City, Crowne Plaza Niagara Falls-Fallsview and Skyline Inn.

The original hotel closed in 1958 and reopened the following year, after the western end was converted into Tussaud's Waxworks, which still stands.

The rest of the original building was demolished in 1964, and the brand new Sheraton-Foxhead Motor Inn was constructed on the site, opening in 1966.

The Sheraton Fallsview has direct indoor connections to attractions, restaurants, and hotels on the 20-acre (81,000 m2) complex including the Fallsview Indoor Waterpark, Casino Niagara, Hershey Store, Rainforest Cafe, and Hard Rock Cafe, Niagara Dining.