La Région-Sherbrookoise was a former regional county municipality in the Canadian province of Quebec.

[3] It ceased to exist when most of it amalgamated into the expanded city of Sherbrooke on January 1, 2002.

La Région-Sherbrookoise RCM consisted of: The City of Bromptonville and the Township of Brompton joined Sherbrooke Regional County Municipality on June 12, 1996.

On January 1, 2002, all of the above except Waterville amalgamated into the newly expanded City of Sherbooke, as part of the 2001–2002 municipal reorganization in Quebec.

Waterville remained independent and moved to Coaticook Regional County Municipality.