She has been seen in multiple Broadway and off-Broadway plays and musicals, on numerous solo and original cast recordings, and in various film and television roles.

[1] Scott moved from Topeka to New York City when she was 18 to attend the Neighborhood Playhouse School of the Theatre where she studied under Sanford Meisner.

[6][7][8] She starred as Amneris in Elton John and Tim Rice's Aida (2000), for which she won the Clarence Derwent Award and was a Drama League Honoree.

The Benefit raised over $200,000 for the Phyllis Newman's Women's Health Initiative of The Actor's Fund and later became the critically acclaimed Broadway show Everyday Rapture.

She originated the role of Ursula in The Little Mermaid (2007) for which she received her second Outer Critics Circle Award nomination for Outstanding Featured Actress in a Musical.

She appeared in Kander and Ebb's Over and Over, at the Signature Theatre, which was a musical adaptation of The Skin of Our Teeth, receiving a nomination for a Helen Hayes Award.

Scott can be heard on numerous Grammy Award-winning and OBC cast albums, the Billboard hit single "A Step Too Far" with Elton John, "The Folks Who Live On The Hill" with jazz great Bill Charlap, as well as the critically acclaimed, "Sherie Rene…Men I've Had," Everyday Rapture the original Broadway cast album, and All Will Be Well: The Piece Of Meat Studio Sessions, produced with Todd Almond.

Scott did a try-out of her new, "critically acclaimed" work,[38][39] Piece of Meat, in collaboration with Todd Almond, in the 2012 Adelaide Cabaret Festival and premiered it in New York City at 54 Below from October 16–27, 2012.