The film details an unrecorded case in which eccentric detective Holmes and his companion Dr. Watson investigate a series of unusual monster attacks and a plot to destroy London.

On December 29, 1940, during the London Blitz, an elderly Dr. John Watson tells his nurse the tale of an unrecorded case he shared with his friend Sherlock Holmes.

Finding escape, several more clues lead Holmes to deduce that the monsters are artificial, built by a criminal genius to acquire resources.

On the case, the dinosaur steals a water pump operating a fountain and rolls of copper wire, presumably in order to create another monster.

Thorpe explains that he built a mechanical suit to cure his paralysis, and he deduced that the crippling bullet ricocheted off a doorframe, fired by Lestrade.

[2] Syfy broadcasts the film under the full title Sir Arthur Conan Doyle's Sherlock Holmes.

Scott Foy of Dread Central criticized the plot synopsis, which indicated that Holmes would be facing "enormous monsters" attacking London.

"[4] In his book Sherlock Holmes On Screen: The Complete Film and TV History, Alan Barnes said that while Keating and David-Lloyd "acquit themselves with a little dignity," he described Ben Syder's Holmes as "punchable" and called the overall film "dismal," "cheap and cheerless," and criticized the "risible final act" in particular.

"[5] Steve Anderson of Screenhead.com gave the film a rating of 6 out of 10, calling it "one of The Asylum's better movies", concluding that it's "far fetched" and "utterly mad" but claiming that it has a "spark of entertainment to it.

"[6] Freddie Young of Fangoria called Sherlock Holmes "probably the best Asylum film to date" but recommended it only to those "willing to check reality at the door and just enjoy the silly ride.