[2] The series is a co-production by DIC Entertainment, L.P. and Scottish Television Enterprises and was nominated for a Daytime Emmy for Special Class Animated Program.

[3] The series was conceptualized by Sandy Ross, a Scottish Television executive, while skiing in Aspen, Colorado in January 1996.

[5] Set during 2103 in New London, Inspector Beth Lestrade of New Scotland Yard is chasing the grotesquely deformed French rogue geneticist Martin Fenwick, when she realizes that his companion is none other than the 19th-century criminal mastermind Professor James Moriarty.

Lestrade knows that Holmes died of natural causes many years later and that his corpse is preserved in a glass-walled, honey-filled coffin in the basement of New Scotland Yard.

Lestrade's compudroid reads the original journals of Dr. John H. Watson and assumes his name, face, voice, and mannerisms in order to assist Holmes in both his crime-solving duties and his difficult assimilation to Great Britain in the 22nd century.

They are often assisted by the new Baker Street Irregulars: the football player Wiggins, the Cockney Deidre, and the paraplegic Tennyson, who communicates through electronic beeps (which Holmes understands after learning about 22nd-century advances in technology and Morse code).

In the U.S., 17 episodes were broadcast on Fox Kids starting in September 1999, in a different order, and ending with "The Man with the Twisted Lip".