Additionally, Silber has studied fertility in animals and performed microscopic surgery on chimpanzees, South American bush dogs, Przewalski's horse, gorillas, wolves, and other endangered species.

[10][11] Beginning in 1996, Silber began experimenting with freezing ovarian tissue to regraft into the ovaries of cancer patients who have compromised fertility after chemotherapy and radiation.

[13] Over his career, Silber has collaborated with medical research teams from the Massachusetts Institute of Technology, the University of Amsterdam, and the Kato Clinic in Tokyo,[1] and has published more than 250 scientific papers and more than 50 teaching videos.

[14] Silber received the 2008 James B. Eads Award for innovation in engineering, technology, or an outstanding project with major impact.

[16] Silber has authored four medical textbooks and five best-sellers on infertility and reproduction,[1][17] including the book How to Get Pregnant,[18] which has been reprinted in several different languages.

He was one of four physicians picked to be on the U.S. Congress Office of Technology Assessment study to help infertile couples in the United States.